Research interest

Areas of Interest

I’m mostly interested in proton imaging and especially proton radiography/proton computed tomography. As part of my work, I investigate the development of detector to acquire proton data, as well as developing new efficient and precise reconstruction algorithm. I also spend a part of my time doing open-source code and side research that I find personally interesting.

Work in progress

Proton radiography in clinical practice. Part I: Pre-treatment patient-specific stopping power by combining proton radiography and X-ray CT, Collins-Fekete, Charles-Antoine; Brousmiche, Sébastien; Hansen, David; Beaulieu, Luc; Seco, Joao

Proton radiography in clinical practice. Part II: A maximum likelihood method for inter-fraction high-resolution proton radiography/proton CT, by Collins-Fekete, Charles-Antoine; Brousmiche, Sébastien; Portillo, Stephen ; Beaulieu, Luc; Seco, Joao

Theoretical Consideration on the most probable proton path estimate

Here I try to simplify the general concept of the proton path estimation by inferring that the generalized Fermi-Eyges moments of the proton distribution null each other out up to a certain factor relative to the distance in the proton crossed. Furthermore, I propose a simplification of the Schulte/Schneider approach to estimate the Highland deviation, along with a measurement of the error introduced (work in progress).

Published research

This article aims to develop an accurate phenomenological model of the cubic spline path estimate of the proton path, accounting for the initial proton energy and water equivalent thickness (WET) traversed.

Range Effects in Proton Therapy Caused by Systematic Errors in the Stoichiometric Calibration

The procedure for proton treatment planning involves the conversion of the patient’s X-ray CT from Hounsfield units into relative stopping powers (RSP), using a stoichiometric calibration curve. In clinical practice, a 3.5% margin is added to account for the range uncertainty introduced by this process and other errors. The purpose of this work is to investigate the impact that systematic errors in the stoichiometric calibration have on the proton range.

Ion Imaging to Better Estimate In-Vivo Relative Stopping Powers Using X-Ray CT Prior-Knowledge Information

The purpose of this study is to reduce uncertainties in relative stopping power (RSP) estimates for ions (alpha and carbon) by using ion radiographic-imaging and X-ray CT prior-knowledge.

– Feasibility Study of MRI-Only Proton Therapy Planning

The aim of this investigation is to assess the dosimetric equivalence of MRI-based proton planning vs. single energy X-ray CT. A cohort of 8 glioblastoma patients was imaged with CT and MRI after surgical resection. T1-weighted 3D-MPRAGE was used to delineate the GTV, which was subsequently rigidly registered to the CT volume. The study showed the clinical feasibility of an MRI-alone proton plan.

 Calcifications in low-dose rate prostate seed brachytherapy treatment: Post-planning dosimetry and predictive factors

The brachytherapy dose algorithm of the American Association of Physicists in Medicine Task Group (TG) Report 43 overrides all tissue materials with water. In reality, dose discrepancies will occur around tissue calcifications. This study investigates these perturbations in low dose rate prostate brachytherapy dosimetry.

– Quantifying the effect of seed orientation in postplanning dosimetry of low-dose-rate prostate brachytherapy

Radioactive seed orientations are usually ignored in clinical brachytherapy dosimetry for prostate implants. Associated with the anisotropic dose distribution of seeds, these orientations could cause dose differences between the planning configurations and the clinical post-planning dosimetry. This study will quantify the impact of seed orientation on the dosimetry.

– Adaptation of the CVT algorithm for catheter optimization in high dose rate brachytherapy

An innovative, simple, and fast method to optimize the number and position of catheters is presented for prostate and breast high dose rate (HDR) brachytherapy, both for arbitrary templates or template-free implants (such as robotic templates).

– On the Sensitivity of α/β Prediction to Dose Calculation Methodology in Prostate Brachytherapy 

To study the relationship between the accuracy of the dose calculation in brachytherapy and the estimations of the radiosensitivity parameter, α/β, for prostate cancer.
– Validating a 192Ir-Based Small Animal Irradiation Apparatus Using a 3D-Printed Applicator: Comparison Between TG-43, Monte Carlo and Films Dosimetry

Accurate assessment of dose delivered is key to early prediction of radiation‐induced anatomic and physiologic changes vital in providing the most accurate patient‐specific treatments. We are conducting a translational small‐animal study using functional Hyperpolarized‐13C‐Urea with DCE‐MRI to evaluate tumor perfusion changes following local targeted Ir‐192 irradiation using the Leipzig applicator. 

Please find more information on my Google Scholar page, Research Gate

Please visit my personal github and feel free to comment/use all my available open-source code.